Clinical significance of Sipa1 expression in gastric cancer
10.3969/j.issn.1000-8179.20130552
- VernacularTitle:Sipa1在胃癌组织中的表达及临床意义
- Author:
Liangqing LI
;
Zhenmeng LIN
;
Dun PAN
- Publication Type:Journal Article
- Keywords:
gastric cancer;
signal-induced proliferation-associated gene 1;
tumor metastasis suppressor gene
- From:
Chinese Journal of Clinical Oncology
2013;(21):1292-1295
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To measure the expression of signal-induced proliferation-associated gene 1 (Sipa1) in gastric cancer and to determine its association with the clinicopathological characteristics and prognosis of patients with gastric carcinoma. Methods:The Sipa1 mRNA and Sipa1 protein expression levels in 43 fresh gastric carcinoma tissues and adjacent normal tissues were measured by real-time PCR and Western blot analysis. The Sipa1 protein expression levels in 122 paraffin blocks of gastric cancer and 64 normal gastric tissues were determined by substance P immunohistochemical technique. Results:The Sipa1 mRNA and Sipa1 protein levels in fresh gastric carcinoma tissues were significantly lower than those in adjacent normal tissues. Sipa1 protein was positive in 36.1%of the paraffin blocks of gastric cancer and in 73.4%of normal gastric tissues. The difference was statistically significant (P<0.05). Sipa1 protein expression was significantly correlated with tumor differentiation, lymphatic metastasis, invasive depth, and clinical stage (P<0.05) but not with age, gender, tumor size, and tumor areas (P>0.05). The five-year survival rates of Sipa1-negative patients were significantly lower than those of Si pa1-positive patients (P<0.01). Conclusion:Sipa1 expression is highly correlated with the biological behavior of gastric carcinoma and thus facilitates the evaluation of gastric carcinoma prognosis.
