Clinical characteristics and treatment of primary ovarian malignant lymphoma
10.3969/j.issn.1000-8179.20131689
- VernacularTitle:原发性卵巢淋巴瘤的临床特点及治疗
- Author:
Jing ZHAO
;
Huaqing WANG
;
Ping WANG
- Publication Type:Journal Article
- Keywords:
Primary ovarian lymphoma;
Clinical characteristic;
Prognosis
- From:
Chinese Journal of Clinical Oncology
2013;(21):1328-1331
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical features and prognostic factors of primary ovarian lymphoma(POL). Methods:A retrospective review was performed based on the clinical records of 14 POL cases treated at Tianjin Medical University Oncology in-stitute Hospital verity from 2000-6 to 2010-5. Results:The median age of patients was 47 years at presentation(range 28~62years). Ab-dominal pain was the most common initial symptom. The majority of histological subtype was B cell lymphoma, above 50%of which is diffuse large B-cell non-Hodgkin's lymphoma. A R0 resection was carried out in 2 patients who were lost to follow-up soon after sur-gery. 11 patients were treated by CHOP, FC or CHOPE chemotherapy. Chemotherapy combined with rituximab were given to 5 pa-tients. Until now, 5 patients were alive, 6 patients died, and only one patient was lost to follow up after therapy. Conclusion:POL is an extremely rare lymphoma. The ultimate diagnosis depends on histopathologic examination. Primary ovarian non-Hodgkin lymphoma should be treated with multi-modality strategies. Treatment with doxorubicin-based chemotherapy after oophorotomy is recommended. B cell lymphoma preferred to use rituximab combination chemotherapy. Abdominal cavity chemotherapy prophylaxis and irradiation can decrease the probability for recurrence .
