Multi-disciplinary diagnosis and treatment of a malignant pheochromocytoma with multiple metastases
10.3969/j.issn.1000-8179.20131397
- VernacularTitle:1例恶性嗜铬细胞瘤多发转移的多学科协作诊疗
- Author:
Yawen ZHENG
;
Xinwei ZHANG
;
Zhongli ZHAN
;
Zhaoxiang YE
;
Wengui XU
;
Peiguo WANG
;
Zhi GUO
;
Xin YAO
;
Guangru XIE
;
Dingzhi HUANG
;
Xiubao REN
- Publication Type:Journal Article
- Keywords:
malignant pheochromocytoma;
multiple metastasis;
CVD regimen;
sunitinib;
multi-disciplinary treatment
- From:
Chinese Journal of Clinical Oncology
2013;(21):1332-1336
- CountryChina
- Language:Chinese
-
Abstract:
Malignant pheochromocytomas are rare tumors that arise from chromaffin tissue, and the diagnostic criterion of malig-nancy is based on the development of metastases. In the case a patient suffers the tumor with liver, lung and bone metastases. However, the test results of tumor markers, gastroscopy, chest and abdominal CT, and PET-CT examination are hard to make a definite diagnosis. The patient was finally diagnosed with malignant pheochromocytoma with liver, lung and bone metastases following the needle biopsy of liver and underwent the excision of a right adrenal pheochromocytoma. Therapeutic standard for the malignant pheochromocytomas is not available so far. It is reported that chemotherapeutic CVD regimen (cyclophosphamide, vincristine, and daecarbazine) and suni-tinib may be effectual in the alike cases. The patient received two cycles of CVD and one cycle of sunitinib, nevertheless, slow progres-sion of the disease remained after the treatment. The results of multi-disciplinary treatment have suggested that 131I-MIBG may just be a choice for this patient.
