Clinical significance of neutrophil and albumin pretreatments in nasopharyngeal carcinoma prognosis
10.3969/j.issn.1000-8179.20130875
- VernacularTitle:治疗前血中性粒细胞数目和白蛋白水平预测鼻咽癌预后的临床意义
- Author:
Xiaofeng TANG
;
Lin ZHANG
;
Jiang LI
- Publication Type:Journal Article
- Keywords:
nasopharyngeal carcinoma;
neutrophil;
albumin;
prognosis
- From:
Chinese Journal of Clinical Oncology
2013;(21):1309-1313
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association of pretherapeutic neutrophil, lymphocyte, monocyte, and serum albumin levels with nasopharyngeal carcinoma (NPC) prognosis in 401 patients. Methods:This study involved 401 NPC patients recently diagnosed and admitted in Sun Yat-sen University Cancer Center, China. Laboratory variables, such as immunology-related parameters and albumin level prior to treatment, were analyzed. The overall survival and disease-free survival rates were determined using the Kaplan-Meier method and were then compared using the log-rank test. Univariate and multivariate analyses were performed using the Cox proportional hazards model to identify prognostic factors. Results:Patients with neutrophil counts>5.20×109/L (n=172) had significantly lower overall survival and disease-free survival rates compared with those with neutrophil counts≤5.20×109/L (n=229) (P=0.014, P=0.009). In the 401 NPC cases, patients with high albumin levels (>43.00 g/L;n=253) had significantly higher overall survival (P=0.000) and disease-free survival (P=0.006) rates compared with those with low albumin levels (≤43.00 g/L;n=148). Multivariate analysis showed that the neutrophil level is an in-dependent risk factor for disease-free survival, whereas the albumin level is a strong independent prognostic factor for overall survival. Conclusion:The pretherapeutic neutrophil and albumin levels are independent prognostic factors for survival in NPC patients.
