The Research Progress on Anti-inflammatory Effects and the Therapy to Acute Lung Injury of Emodin
- VernacularTitle:大黄素抗炎作用及对急性肺损伤治疗作用研究进展
- Author:
Aijuan SHEN
;
Wanru CAI
- Publication Type:Journal Article
- Keywords:
emodin;
anti-inflammatory mechanism;
acute lung injury;
inflammatory cytokins;
NF-kB
- From:
Journal of Zhejiang Chinese Medical University
2013;(10):1261-1264
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To explore the anti-inflammatory effects of emodin and its therapeutic effect on acute lung injury. [Methods] By means of analyzing the relevant literatures in PUBMED,CNKI,CBM,Wanfang and Vip Da-tabase from 1998 to 2012,summarized the anti-inflammatory effects and mecha-nisms of emodin, as wel as its therapeutic effect on acute lung injury. [Results] A variety of studies have confirmed the anti-inflammatory effects of emodin, whose mechanism is related to emodin inhibiting the activation of NF-kappa B,modulaing various inflammatory factors, etc. In addition, the effect of emodin in the treatment of acute lung injury has been confirmed on celland animal levels. [Conclusion] Emodin has good prospect of clinical application.
