Increased expression of autoantibody protein and soluble IL-6 receptor in serum of patients with Tourette's syndrome
- VernacularTitle:抽动秽语综合征患者血清自身抗体与可溶性白介素-6受体表达增高
- Author:
Yuhang CHENG
;
Yi ZHENG
;
Lifang WANG
;
Ruimei LIU
;
Yang GAO
- Publication Type:Journal Article
- Keywords:
Tourette's syndrome;
autoantibodies;
anti-streptolysin O;
sIL-6R;
sgp130
- From:
Basic & Clinical Medicine
2010;30(2):113-116
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the mechanism of immunologic injury in patients with Tourette's syndrome(TS). Methods The serum level of anti-brain antibody ( ABAb) , antinuclear antibody ( ANAb) , soluble IL-6 receptor (sIL-6R) and soluble gpl30(sgp130) in patients with TS were analyzed by commercially available ELISA kits,and the titer of anti-streptolysin O ( ASO) in TS and in control was examined with latex enhanced immunoturbidimetry. Results The level of sIL-6R and sgpl30 was significantly elevated in TS compared with control group [(44. 1 ± 15.8)ng/mL vs (30. 3 ± 9. 0) ng/mL and (69. 0 ±24. 6)ng/mL vs (47. 3 ±14. l)ng/mL,P <0. 01 respectively]. ASO titer(250 U/mL) was found higher in TS than that in control(P <0. 01). The positive rates of anti-brain an-tibody and antinuclear antibody in TS were higher than that in control group (66% vs 4% and 53% vs 25% , P <0. 01 respectively). The level of ABAb negatively correlated with sgpl30 concentration( r = 0. 375, P <0. 05 ). Conclusion IL-6 signal transduction might be involved in Tourette's syndrome to lead the function enhancementand start cascade of feedback inhibition, because of elevated levels of slL-6R, sgp130, ANAb and ABAb in serum.Autoimmune-related injuries may potentially explain the pathogenesis of the disease.
