Emm types and superantigen analysis of streptococcus pyogenes isolated from Chinese children
- VernacularTitle:中国儿童A族链球菌感染菌株emm分型及超抗原基因谱分布
- Author:
Yaoling MA
;
Yonghong YANG
;
Sangjie YU
;
Kaihu YAO
;
Lin YUAN
;
Xuzhuang SHEN
- Publication Type:Journal Article
- Keywords:
group A streptococcus;
emm gene sequence;
superantigen
- From:
Basic & Clinical Medicine
2009;29(11):1166-1169
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the distribution of the emm types and superantigens of group A streptococcal ( GAS) isolated from Chinese children. Methods Totally 222 GAS isolates collected from five Children's Hospitals of China during 2005～2006 were studied, emm types were performed by PCR and sequencing. The eight superan-tigen (SAg) genes (speA, speC, speH, speI, speG, speJ, ssa and SMEZ) were checked by PCR. Results Nine emm types were identified, of which emml2 (55. 86% ) and emml (39. 64% ) were the most prevalent types. The GAS isolates carried six or more SAg genes take 78. 39% of all the isolates in this study. The SAg gene profiles were closely associated with the emm type. Conclusion The emm type of S. pyogenes isolated from Chinese chil-dren was quite wide-spreading and SAg genes appeared to be associated with the emm type so its expression is po-tential in vaccine development.
