Mitogen-activated protein kinases and morphine tolerance
- VernacularTitle:丝裂原活化的蛋白激酶通路与吗啡耐受
- Author:
Yanbo ZHANG
;
Baoliang SUN
;
Hui YUAN
;
Mingfeng YANG
;
Jingzhong NIU
;
Guowei LU
- Publication Type:Journal Article
- Keywords:
mitogen-activated proteins kinases;
morphine tolerance;
MAPKs inhibitiors
- From:
Basic & Clinical Medicine
2010;30(3):325-328
- CountryChina
- Language:Chinese
-
Abstract:
The MAPKs activation pathway consists of three protein kinases in activation sequence:MAPKs kinase kinases (MKKKs)→,MAPKs kinases (MKKs)→MAPKs and four pathways:extracellular signal-regulated kinase (MAPK~(ERK)),C-JUN N-terminal kinase (MAPK~(JNK)),MAPK~(P38) and MKKS/MAPK~(ERK5) activation pathways.It has been proved that MAPKs(ERK,JNK and P38) are acvtivated in the progress of morphine tolerance.Inhibitors of any element of MAPKs activation pathway may function as a potential clinical medicine for morphine tolerance.
