IL-6 can upregulate porcine ovarian granulosa cells androgen receptor expression
- VernacularTitle:IL-6可增强猪卵巢颗粒细胞雄激素受体的表达
- Author:
Ling HONG
;
Xiaoming TENG
;
Kunming LI
;
Wenqiang HUANG
;
Yan ZHANG
;
Bo ZHANG
;
Xiaowen TONG
- Publication Type:Journal Article
- Keywords:
interleukin 6;
PCOS;
ovarian granulosa cell;
androgen receptor
- From:
Basic & Clinical Medicine
2010;30(3):303-305
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of intedeukin 6 (IL-6) on the expression of androgen receptor (AR) in porcine ovarian granulosa cells(GC) and to explore its role of in the polycystic ovary syndrome(PCOS) pathogenesis.Methods Different concentrations of IL-6 (10,100 and 1 000 ng/L) were treated with GC.Expression of androgen receptor (AR) mRNA and protein in GC were detected by real-time quantitative RT-PCR and Western blot.Results The mRNA and protein expressions of AR in GC were upregulated in groups with 100 and 1 000 ng/L IL-6 at 72 h.Conclusion IL-6 can improve androgen activity.This process may explain the function of chronic subclinical inflammation in PCOS pathogenesis.
