Research progresses on K-RAS mutation of non-small cell lung cancer
- VernacularTitle:非小细胞肺癌中K-RAS基因突变最新临床意义
- Author:
Xianhua FU
;
Jianjin HUANG
- Publication Type:Journal Article
- Keywords:
K-RAS;
non-small cell cancer
- From:
Basic & Clinical Medicine
2010;30(2):212-214
- CountryChina
- Language:Chinese
-
Abstract:
Mutated K-RAS is found in 15%～30% NSCLC patients, the mutations of K-RAS and EGFR are mutually exclusive,K-RAS mutations have poor sensitivity to EGFR-TKIs. The response of C-225 is not restricted to mutated K-RAS, NSCLC patients with K-RAS mutations are associated with unfavorable prognosis. A number of different approaches such as Ftase inhibitors, RAF inhibitors, MEK inhibitors aimed at abrogating K-RAS activity to improve clinical response have been explored in clinical trials.
