ERS response mediates glucolipotoxicity-induced β-cell apoptosis
- VernacularTitle:内质网应激参与糖脂毒性引起的胰岛β细胞凋亡
- Author:
Yanli YANG
;
Ruolan XIANG
;
Qi SUN
- Publication Type:Journal Article
- Keywords:
endoplasmic reticulum stress;
glucolipotoxicity;
β-cell apoptosis
- From:
Basic & Clinical Medicine
2009;29(12):1337-1340
- CountryChina
- Language:Chinese
-
Abstract:
As one of the most sensitive cells of endoplasmic retieulum stress (ERS), pancreatic β-cells have an a-bundance of endoplasmic reticulum. Fatty acids cause apoptosis of β-cells and might contribute to β-cell loss in type 2 diabetes mellitus via the induction of ERS. Glucose is an amplifier of the ERS response to fatty acid, leading to increased β-cell apoptosis. ERS response mediates glucolipotoxicity-induced β-cell apoptosis.
