Relationship between polymorphisms of CX3CR1 gene and coronary artery disease: a Meta-analysis
- VernacularTitle:CX3CR1基因多态性与冠心病关联的荟萃分析
- Author:
Wenlong LI
;
Xiaojian WANG
;
Jing XU
;
Jingzhou CHEN
;
Channa ZHANG
;
Kai SUN
;
Rutai HUI
- Publication Type:Journal Article
- Keywords:
coronary artery disease;
CX3CR1;
gene polymorphism
- From:
Basic & Clinical Medicine
2009;29(11):1170-1173
- CountryChina
- Language:Chinese
-
Abstract:
Objective To find whether CX3CR1 V249I and T280M are associated with CAD. Methods Database in English and Chinese, including PUBMED, EMbase, were searched to get the case-control studies on the associa-tion between V249I, T280M and CAD. Results Six studies were reviewed. The pooled OR of V249I compared to wild type allele was OR =0. 85(95% CI =0. 67 ～ 1. 08,P >0. 05). The pooled OR of T280M compared to wild type allele was OR =0. 82(95% CI =0. 70 ～ 0. 96, P < 0. 05). Conclusion The T280M is a protective factor of CAD, while the V249I is not associated with CAD.
