Relationship between angiontensin Ⅱ type2-receptor gene polymorphism and essential hypertension in men
- VernacularTitle:血管紧张素Ⅱ2型受体基因多态性与男性原发性高血压相关
- Author:
Chuanfang LI
;
Dongsheng GAO
- Publication Type:Journal Article
- Keywords:
essential hypertension (EH);
male;
angiontensin Ⅱ type2-receptor(AGTR2);
gene polymorphism;
genotype
- From:
Basic & Clinical Medicine
2010;30(3):280-283
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between AT2-receptor 1675A/G gene polymorphism and essential hypertension in men.Methods The 113 EH male patients and 101 controls were born in Jining.The 1675A/G polymorphism of AGTR2 gene was detected by PCR,HRM and gene sequencing.Results There was difference in genetypes(AA,GG) distribution and allele frenqency of AGTR2 1675A/G between male EH and control group (P＜0.05).Genotypes(AA,GG) distribution in EH group[56(49.6%) and 57(50.4%)]are significantly higher than that in control group [32 (31.7%) and 69 (68.3%)](P＜0.05).Allele frenqency in EH group[A:112(49.6%) and G:114(50.4%)]is significantly higher than that in control group[64(31.7%) and 138(68.3%)](P＜0.05).Conclusion The 1675A/G polymorphism of AGTR2 gene may be associated with male EH in Jining area,Shandong province.
