Preparation and application of multicellular spheroid in cancer therapy
- VernacularTitle:多细胞球样体的制备及其在肿瘤治疗研究中的应用
- Author:
Qiang XU
;
Quan LIAO
;
Yupei ZHAO
- Publication Type:Journal Article
- Keywords:
multicellular spheroid;
3-D culture;
anti-tumor therapy;
cocuhure
- From:
Basic & Clinical Medicine
2010;30(3):320-324
- CountryChina
- Language:Chinese
-
Abstract:
Multicellular spheroid (MCS) can simulate many aspects of the in vivo physiological and pathological conditions in many aspects,better reflect the in-vivo behavior of cells in tumors.So it's increasingly accepted as a valuable tool for evaluating the efficacy of therapeutic intervention including chemotherapy,radiotherapy,immunotherapy and combined therapy.Various spheroid co-culture approaches have been presented to study heterologous cells interaction in solid tumors.The present review briefly introduces the methodology and applications of MCS with focus on the up-to-date information.
