Primary investigation on therapeutic effect of stem cell transplantation in patients with leukemia based on changes in haptoglobin
- VernacularTitle:基于触珠蛋白变化的白血病干细胞移植治疗疗效初探
- Author:
Peixuan BI
;
Yang ZENG
;
Zhili LI
;
Chunhua ZHAO
- Publication Type:Journal Article
- Keywords:
stem cell transplantation;
haptoglobin;
2-DE;
leukemia;
mass spectrometry
- From:
Basic & Clinical Medicine
2010;30(5):454-458
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of different approaches of stem cell therapy in patients with leukemia on haptoglobin(Hp).Methods The trial includes four patients treated by mesenchymal stem cell(MSC)with hematopoietic stem cell cotransplantation(HSCT)and two patients treated by hematopoietic stem cell transplantation(HSCT).Haptoglobin in the plasma,collected from different therapeutic stages,of six patients was separated by two-dimensional gel electrophoresis(2-DE),and then followed by the identification with MALDI-TOF/TOF mass spectrometry.Results The abundance of haptoglobin alpha and beta chains with different modifications decreased along with an extending therapeutic time window.This tendency was more significant in HSCT group.Conclusion The haptoglobin may be a potential biomarker for the prognosis in patients with leukemia treated by stem cell transplantation.
