Role of centrosome in tumorigenesis and oncotherapy
- VernacularTitle:中心体在肿瘤发生及治疗中的作用
- Author:
Li XUE
;
Yujie BAI
- Publication Type:Journal Article
- Keywords:
ontology;
centrosome;
mitosis;
oncotherapy
- From:
Basic & Clinical Medicine
2010;30(4):431-433
- CountryChina
- Language:Chinese
-
Abstract:
The centrosome plays a crucial role in the maintaining of cell conformation,mitosis and chromosome seg-regation.It responds to the DNA damage and keeps the genome stability via cross-talking with the intranuclear DNA damage repair system.The apoptosis of tumor cells can be induced through inhibition of the duplication of centro-some.So the inhibitors of centrosomal proteins will be a potential anti-tumor therapy.