Reprogramming the human skin fibroblast cell into stem cell
- VernacularTitle:把人体皮肤成纤维细胞重编程为干细胞
- Author:
Bingzheng ZHONG
;
Qiaobing HUANG
- Publication Type:Journal Article
- Keywords:
human fibroblasts;
stem cells
- From:
Basic & Clinical Medicine
2010;30(2):209-211
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, researchers have made some breakthroughs on human embryonic stem cells, in particular, on reprogramming differentiated cell (such as human skin fibroblast) into human embryonic stem cell. Induced pluripotent stem cells could be generated from human skin fibroblasts by inducting into four transcription factors known as OCT3/4, SOX2, C-MYC and KLF4. This approach enables better understanding the pathogenesis of diseases from the perspective of genetic component and promising in the treatment of related diseases. This article introduces the latest advancement of those researches.
