Serum hydrogen sulfide reduces in idiopathic pulmonary fibrosis patients
- VernacularTitle:特发性肺纤维化患者血硫化氢水平下降
- Author:
Dan SUN
;
Liping FANG
;
Bin GENG
;
Xinmin LIU
;
Chaoshu TANG
- Publication Type:Journal Article
- Keywords:
idiopathic pulmonary fibrosis;
hydrogen sulfide
- From:
Basic & Clinical Medicine
2010;30(2):122-124
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of endogenous H_2S in idiopathic pulmonary fibrosis(IPF) patients, and its relationship with the severity of IPF. Methods Plasma H_2S in 27 patients with IPF (IPF group) and 28 healthy people (control group) were tested. PaO_2, ESR, CRP, LDH, HRCT and pulmonary function in IPF group were tested to evaluate the severity of the disease at the same time. Then the concentrations of H_2S in aggravating and palliative period in IPF group were observed. Results (1) Compared with the control group, the concentration of plasma H_2S in IPF group was significantly reduced(P <0. 01). (2) The concentration of H_2S in aggravating period was higher than that during palliative period(P <0. 01) . (3) With the progress of HRCT,there was a descending trend of plasma H_2S(P >0. 05). Conclusion Endogenous H_2S was probably involved in the course of IPF, and was associated with the progress of the disease.
