High expression of angiopoietin-2 and endostatin in endometriosis
- VernacularTitle:血管生成素-2和内皮抑素在子宫内膜异位症中的高表达
- Author:
Jun FAN
;
Wentao DONG
;
Baozhi SUN
;
Xiaolin LI
;
Bo LIU
;
Chun WANG
- Publication Type:Journal Article
- Keywords:
angiopoietin-2;
endostatin;
endometriosis;
peritoneal fluid
- From:
Basic & Clinical Medicine
2009;29(11):1203-1206
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of Angiopoietin-2(ANG-2) and Endostatin (ENS) in patho genesis and development of endometriosis. Methods Twenty-five endometriosis cases and 24 controls were enrolled. ANG-2 and ENS in endometrium were detected by Immunohistochemistry. The concentrations of ANG-2 and ENS in peri-toneal fluid were measured with enzyme linked immunoabsorbant assay. Results In the EMs group, ANG-2 positive rate in eutopic endometrium was significantly higher than that of ectopic endometrium. The ANG-2 positive rate in ectopic endometrium was significantly higher than that of control group; in EMs group, the ENS positive rate in ec-topic endometrium was significantly higher than that in eutopic endometrium. The ENS positive rate in eutopic endo-metrium was significantly higher than that in control group. There was no significant difference of ANG-2 or ENS between stage Ⅰ～Ⅱand stage Ⅲ～Ⅳ. In peritoneal fluid, ANG-2 and ENS concentration and ratio of ANG-2/ ENS in endometriosis were significantly higher than that in controls. Conclusion The effect of angiopoietin-2 and endostatin in angiogenesis of endometriosis are important play a role in pathogenesis and development of the endo-metriosis.
