Comparison of interfitial remodeling in different rabbit models with diastolic heart failure and systolic heart failure
- VernacularTitle:兔舒张性心衰和收缩性心衰模型建立及间质重构的比较
- Author:
Lei WANG
;
Haipeng WANG
;
Caiming ZHAO
;
Lianhua HAN
;
Cao ZOU
;
Zhihua LIU
;
Wenping JIANG
- Publication Type:Journal Article
- Keywords:
diastolic heart failure;
systolic heart failure;
cardiac function;
collagen
- From:
Basic & Clinical Medicine
2009;29(12):1244-1248
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the differences of cardiac function and interstitial remodeling between diastolic heart failure(DHF) and systolic heart failure(SHF) rabbit models. Methods To establish DHF model with abdo-mial aorta constriction and SHF model with abdomial aorta constriction plus aortic insufficiency. The cardiac func-tion was examined by UCG parameters and homodynamic parameters. The collagen content was measured through hydroxyproline colorimetric assay and shown as collagen area(CA), collagen volume fraction(CVF) and area ratio of Ⅰ to Ⅲ type collagen with PSR. Results Compared with control group, there were significantly increased thick-ness and stiffness of myocardium, impaired diastolic function but normal ejection fraction (EF), and significantly increased collagen content, CA, CVF and area ratio of Ⅰ to Ⅲ type collagen in DHF group; heart chamber was sig-nificantly enlarged, systolic function decreased, and collagen content, CA, CVF significantly increased, but ratio of Ⅰ to Ⅲ type collagen decreased in SHF group(P <0.05 or P <0.01). Conclusion DHF and SHF rabbit mod-els were established successfully, which can simulate clinical profiles and provide technical support to future re-search.
