Chemokine receptor CXCR7 in tumor invasion and metastasis
10.3760/cma.j.issn.1673-422X.2013.10.007
- VernacularTitle:CXCR7在肿瘤侵袭和转移中的研究
- Author:
Chao GAO
;
Yu ZHI
;
Xiangying FENG
- Publication Type:Journal Article
- Keywords:
CXCR7;
Neoplasms;
Extracellular matrix;
Epithelial-mesenchymal transition
- From:
Journal of International Oncology
2013;40(10):742-744
- CountryChina
- Language:Chinese
-
Abstract:
Chemokines are major regulators of cell transformation and adhesion.Recent study has demonstrated that CXCR7 can bind to CXCL11 and CXCL12 with high affinity,and the activated CXCR7 may influence tumor invasion and metastasis by regulating extracellular matrix (ECM) and epithelial-mesenchymal transition (EMT) and other signal transduction pathways.Therefore,in-depth study of the molecular mechanisms of CXCR7 in tumor invasion and metastasis may provide a more effective theoretical basis for tumor treatment.
