Orthodontic force effects on the expression of periodontal interleukin-6 mRNA in rats

VernacularTitle:正畸力作用下大鼠牙周组织白细胞介素6 mRNA的表达
Author: Yajing QIAN ; Jing NIE ; Xu PAN ; Minghua HU ; Congbo MI
Publication Type:Journal Article
From: Chinese Journal of Tissue Engineering Research 2013;(50):8672-8677
CountryChina
Language:Chinese
Abstract: BACKGROUND:As an important cytokine, interleukin-6 regulates immune responses in inflammation sites and has an autocrine/paracrine activity that stimulates osteoclast formation and bone resorption, which is related to bone remodeling during orthodontic tooth movement.
OBJECTIVE:To investigate the effects of orthodontic force on the expression of interleukin-6 mRNA in the periodontal tissue of rats.
METHODS:In situ hybridization was performed to measure the expression of interleukin-6 mRNA at 1, 3, 5, 7, 10 and 14 days after the application of orthodontic force on the maxil ary first molars of rats.
RESULTS AND CONCLUSION:The expression of interleukin-6 mRNA was observed at a low level in the normal periodontal tissue of rats. After the application of force, the induction of interleukin-6 mRNA was observed to reach a maximum on day 3 and to decline thereafter. The expression of interleukin-6 mRNA can be evoked by orthodontic force but with a certain self-limiting. As a multifunctional cytokine, interleukin-6 plays a very important role in periodontal remodeling during orthodontic tooth movement.