The Significance of Minimal Residual Disease Detection in Acute Leukemia
- VernacularTitle:急性白血病完全缓解微小残留病检测的意义
- Author:
Ping LU
- Publication Type:Journal Article
- Keywords:
Leukemia;
Minimal residual disease;
Significance
- From:
Journal of Kunming Medical University
2013;(11):108-110
- CountryChina
- Language:Chinese
-
Abstract:
Objective Investigate the clinical significance of bone marrow minimal residual disease (MRD) detection to prognosis and therapeutic evaluation in acute leukemia (AL) after complete remission (CR). Methods Forty-three cases of bone marrow specimens in patients with acute leukemia were collected from 209-2012. The MRD was detected using multiparameter flow cytometry (FCM). The detection was performed from the beginning of induction chemotherapy by CR,and detected at 1,3,6 and 12 months. According to the CR detection for the first time, the induced MRD levels were obtained after treatment, then 43 patients with AL were divided into negative (MRD<10-4) and positive (MRD>10-4) two groups. Results The recurrence rate after three years of the two groups was 0 and 80%, respectively. There was a significant difference in the recurrence rate ( <0.05) . The recurrence rate of positive group was significant higher than that of negative group ( <0.05) when the morphologic of MRD was complete remission. Conclusion Using FCM to detect AL MRD, MRD>10-4 AL-CR have the high recurrence rate, and the recurrence of positive group have appeared early than traditional MRD bone marrow morphology. The continuous MRD detection of AL-CR has important clinical significance in the prognosis and early prediction for recurrence.
