The Clinical Measures Associated with C-peptide Decline in Patients with Type 1 Diabetes over 15 Years.
10.3346/jkms.2013.28.9.1340
- Author:
Tae Ho LEE
1
;
Ah Reum KWON
;
Ye Jin KIM
;
Hyun Wook CHAE
;
Ho Seong KIM
;
Duk Hee KIM
Author Information
1. Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea. hopechae@yuhs.ac
- Publication Type:Original Article
- Keywords:
Diabetes Mellitus, Type 1;
C-Peptide;
Body Weight;
Body Mass Index;
Diabetic Ketoacidosis
- MeSH:
Adolescent;
Body Mass Index;
Body Weight;
C-Peptide/*blood;
Child;
Child, Preschool;
Diabetes Complications;
Diabetes Mellitus, Type 1/blood/*diagnosis;
Diabetic Ketoacidosis/epidemiology;
Diabetic Retinopathy/epidemiology;
Female;
Follow-Up Studies;
Hemoglobin A, Glycosylated/analysis;
Humans;
Incidence;
Infant;
Male;
Peripheral Nervous System Diseases/epidemiology;
Retrospective Studies
- From:Journal of Korean Medical Science
2013;28(9):1340-1344
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study was done to characterize the natural course of C-peptide levels in patients with type 1 diabetes and identify distinguishing characters among patients with lower rates of C-peptide decline. A sample of 95 children with type 1 diabetes was analyzed to retrospectively track serum levels of C-peptide, HbA1c, weight, BMI, and diabetic complications for the 15 yr after diagnosis. The clinical characteristics were compared between the patients with low and high C-peptide levels, respectively. The average C-peptide level among all patients was significantly reduced five years after diagnosis (P < 0.001). The incidence of diabetic ketoacidosis was significantly lower among the patients with high levels of C-peptide (P = 0.038). The body weight and BMI standard deviation scores (SDS) 15 yr after diagnosis were significantly higher among the patients with low C-peptide levels (weight SDS, P = 0.012; BMI SDS, P = 0.044). In conclusion, C-peptide level was significantly decreased after 5 yr from diagnosis. Type 1 diabetes patients whose beta-cell functions were preserved might have low incidence of diabetic ketoacidosis. The declines of C-peptide level after diagnosis in type 1 diabetes may be associated with changes of body weight and BMI.
