Aging-variation of neurotrophic factors and their receptors in lumbar spinal cord of age-increasing rats
- VernacularTitle:大鼠脊髓腰节段神经营养因子及其受体的增龄变化
- Author:
Yali LI
;
Ning ZHAO
;
Li ZHANG
;
Lin LI
- Publication Type:Journal Article
- Keywords:
spinal cord;
aging;
neurotrophic factors;
rat
- From:
Basic & Clinical Medicine
2009;29(11):1126-1132
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes in neurotrophic factors and their receptors in the lumbar spinal cord of aging rats (1, 3, 6, 12, 18 and 24 months) , and to investigate their correlation with gowth. Methods The expression of neurotrophic factors and their receptors in the lumbar spinal cord of rats were measured by immunohistochemis-try and western blot. Nissl staining was used for quantitative detection of survival neurons. Results The expression of nerve growth factor (NGF) and its receptor TrkA, brain derived neurotrophic factor (BDNF) and its receptor TrkB and gliocyte derived neurotrophic factor (GDNF) in lumbar spinal cord of rats showed changes in relation to the aging process. Their expression was lower at the age of 1 month, reached the peak at 6-month, and decreased significantly at 24 months, in which the decline of GDNF was more obvious. The number of survival neurons in lumbar spinal cord kept at a high level from 1 to 6-month, then decreased gradually, and reached the lowest level at the age of 24 months. Conclusion The expression of neurotrophic factors and their receptors change with aging process, decreases in aged rats especially,which may be one of the mechanisms involved in spinal cord aging.
