Epidemiological study of the genes conferring aminoglycoside resistance in 36 strains of multidrug-resistant Acinetobacter baumannii
- VernacularTitle:36株多重耐药鲍曼不动杆菌对氨基糖苷类药物耐药基因的流行病学研究
- Author:
Lidan XING
;
Zuhuang MI
;
Xinxin XU
;
Ting WANG
;
Shasha TIAN
;
Hongyan YUAN
;
Pan ZHANG
;
Xiaoyun JI
;
Zhaoliang SU
;
Huaxi XU
- Publication Type:Journal Article
- Keywords:
Acinetobacter baumannii;
multidrug-resistance;
aminoglycoside resistance gene
- From:
Chinese Journal of Infection and Chemotherapy
2013;(6):442-445
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prevalence of genes conferring aminoglycoside resistance in multidrug-resistant strains of Acinetobacter baumannii (MDR-ABA).Methods Multidrug-resistant A.baumannii strains were isolated during the period from August to November 2012 from patients in the affiliated hospital of Jiangsu University and the First Hospital of Zhen-jiang.Kirby-Bauer diffusion method was used to determine the susceptibility of these strains to antimicrobial agents.PCR was performed to detect the aminoglycoside resistance genes.Results The 36 MDR-ABA strains showed high resistance rates to most antimicrobial agents except cefoperazone-sulbactam.The prevalence of the genes conferring aminoglycoside resistance, aac (3)-I,aac (6’)-Ib,aph (3’)-I and armA,was 72.2% (26/36),72.2% (26/36),80.6% (29/36)and 80.6% (29/36), respectively.Conclusions The MDR-ABA strains in this study are highly resistant to antimicrobial agents,which is closely as-sociated with the genes conferring aminoglycoside resistance.