Surveillance of antimicrobial resistance of Haemophilus influenzae in Peking U-nion Medical College Hospital during 2008 and 2011
- VernacularTitle:2008-2011年北京协和医院流感嗜血杆菌耐药性监测
- Author:
Cui NIU
;
Hui ZHANG
;
Qiwen YANG
;
Na LI
- Publication Type:Journal Article
- Keywords:
Haemophilus influenzae;
beta-lactamase positive ampicillin resistant (BLPAR);
beta-lactamase negative ampicil-lin resistant (BLNAR);
resistance mechanism
- From:
Chinese Journal of Infection and Chemotherapy
2013;(6):476-480
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the antimicrobial resistance of Haemophilus influenzae in Peking Union Medical College Hospital for rational clinical treatment.Methods A total of 223 strains of H .influenzae were collected from patients from Jan-uary 2008 to December 2011.The antimicrobial susceptibility was tested by Kirby-Bauer method.Production of beta-lactamase was detected using nitrocefin disks.WHONET 5.6 software was used to analyze the data of susceptibility testing.Results Tri-methoprim-sulfamethoxazole and tetracycline were the two antimicrobial agents to which the H .influenzae strains were most resistant.Theβ-lactamase positive ampicillin resistant strains accounted for 15.9 %,andβ-lactamase negative ampicillin resist-ant strains accounted for 8.9%.Conclusions H .influenzae is mainly isolated from respiratory specimens.Majority of the anti-microbial agents still show good antibacterial activity against H .influenzae strains.However,H .influenzae isolates are highly resistant to trimethoprim-sulfamethoxazole and tetracycline.
