A strain of extensively drug resistant and KPC-2 carbapenemase-producing Kleb-siella pneumoniae is identified in Dongguan,Guangdong province
- VernacularTitle:广东省东莞地区发现1株泛耐药产 KPC-2型碳青霉烯酶的肺炎克雷伯菌
- Author:
Li ZHANG
;
Xiaobing ZHANG
;
Weiqing YANG
;
Juan HUANG
;
Lihua ZHANG
;
Jufen ZHANG
;
Xuehai ZHU
;
Kaixin ZHU
;
Jing ZHOU
- Publication Type:Journal Article
- Keywords:
extensive drug resistance;
carbapenemase KPC-2;
Kebsiella pneumoniae
- From:
Chinese Journal of Infection and Chemotherapy
2013;(6):465-468
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the extensively drug resistant mechanism and clinical treatment strategy of Klebsiella pneu-moniae .Methods The isolate was identified by Vitek2 Compact System.Antimicrobial susceptibility testing was conducted by Kirby-Bauer method.KPC-2 carbapenemase was detected by modified Hodge test.The gene encoding KPC-2 carbapenemase was amplified by polymerase chain reaction (PCR)and then sequenced.Results The strain was resistant to all antibiotics used in routine antimicrobial susceptibility testing except amikacin.Modified Hodge test showed positive result.KPC-2 gene was detected by PCR.The sequence was consistent with that of 11844849 in GenBank.After treatment for one month,no exten-sively drug resistant K.pneumoniae strain was detected from the patient.Conclusions It is necessary to strengthen the monito-ring and improve the awareness of extensively drug resistant K.pneumoniae for better control of such infections.
