Construction of tissue-engineered heart valves:Status and Prospects
10.3969/j.issn.2095-4344.2013.50.024
- VernacularTitle:组织工程心脏瓣膜的构建：现状与前景
- Author:
Yanli SUN
;
Hongguang HAN
;
Daifa HUANG
;
Shunchuan HE
;
Yujie LI
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2013;(50):8775-8780
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Current cardiac bioprostheses and mechanical valves are shown to have some flaws and shortcomings, and tissue-engineered heart valves which can avoid these problems are becoming an ideal choice for valve replacement.
OBJECTIVE:To explore the experimental progress in the construction of tissue-engineered heart valves.
METHODS:Experimental studies related to tissue-engineered heart valves were retrieved in databases. Three main elements for tissue-engineered heart valves are seed cells, scaffold materials, and cellseeding.
RESULTS AND CONCLUSION:Cardiac valve repair and replacement is the primarily surgical treatment for valvular heart disease. At present, seed cells mainly for construction of tissue-engineered heart valves include vascular endothelial cells, endothelial progenitor cells and bone marrow mesenchymal stem cells. The acellular scaffold has good biomechanical properties and histocompatibility. After cellseeding, a continuous celllayer wil form on the scaffold surface, which makes it possible to construct tissue-engineered heart valves. Tissue-engineered heart valve has a good prospect, but it is stil in the early stage of research and there are stil many problems that need to be solved.
