Reserch progress of nasopharyngeal carcinoma related gene
10.3760/cma.j.issn.1673-422X.2013.09.007
- VernacularTitle:鼻咽癌相关基因研究进展
- Author:
Honglei CHENG
;
Ruoyu WANG
- Publication Type:Journal Article
- Keywords:
Nasopharyngeal neoplasms;
Genes
- From:
Journal of International Oncology
2013;40(9):662-665
- CountryChina
- Language:Chinese
-
Abstract:
The occurrence of nasopharyngeal carcinoma is a multi-gene,multi-step process.Among them,oncogene activation and antioncogene inactivation is the important mechanism.The related oncogenes of nasopharyngeal carcinoma contain Bcl-2,hepatocyte growth factor (HGF),cyclooxygenase-2 (COX-2) and latent membrane protein-1 (LMP-1).The related antioncogenes of nasopharyngeal carcinoma contain p53,p16,Nm23-H1 and PTEN.With the deepening research on genes,studies also find that nasopharyngeal carcinoma is related to PECAM-1,MMP-9 and RECK.These genes play important roles in the occurrence and development of nasopharyngeal carcinoma,which may become new targets for the treatment of nasopharyngeal carcinoma.
