Autologous stem cells transplantation in the treatment of critical limb ischemia

VernacularTitle:自体干细胞移植治疗严重下肢缺血
Author: Mao LI ; Wen HUANG
Publication Type:Journal Article
From: Chinese Journal of Tissue Engineering Research 2013;(49):8602-8607
CountryChina
Language:Chinese
Abstract: BACKGROUND:Critical limb ischemia is difficult to be treated among the peripheral arterial occlusive diseases, and the application of transplanting autologous stem cells can bring a hope for the treatment of this disease.
OBJECTIVE: To review the autologous stem cells transplantation in the treatment of critical limb ischemia at present, and to study the mechanism and the existing problems.
METHODS:A computer retrieval of PubMed database, Wanfang database, and CNKI database was conducted to search the related articles with the keywords of“stem cell, transplant, critical limb ischemia”in English and Chinese. Final y, 47 articles were included in final analysis according to the inclusion criteria.
RESULTS AND CONCLUSION:Autologous stem cells transplantation for treatment of lower extremity ischemic disease is a latest and significantly effective treatment, but the mechanism is unclear and stil needs further study.