Effective volume of 1.5％ lidocaine for obturator nerve block in 50％ of patients undergoing transurethral resection of bladder tumor

VernacularTitle:1.5％利多卡因用于经尿道膀胱肿瘤电切术患者闭孔神经阻滞时的半数有效容量
Author: Yuechun LU ; Jian SUN ; Chunlin GAO ; Guoyi Lü ; Guolin WANG
Publication Type:Journal Article
Keywords: Lidocaine; Nerve block; Obturator nerve; Dose-response relationship,drug
From: Chinese Journal of Anesthesiology 2013;33(10):1233-1235
CountryChina
Language:Chinese
Abstract: Objective To determine the effective volume of 1.5％ lidocaine for obturator nerve block (ONB) in 50％ of patients (EV50) undergoing transurethral resection of bladder tumor (TURBT).Methods Thirty-six ASA physical status Ⅰ or Ⅱ patients with bladder tumor,aged 18-64 yr,with body mass index of 19-30 kg/m2,scheduled for elective TURBT and required ONB before TURBT,were enrolled in the study.ONB was performed with 1.5 ％ lidocaine using the pubic approach under the guidance of a nerve stimulator.The volume of 1.5％ lidocaine was determined by up-and-down sequential trial.The initial volume of hdocaine was 10 ml and the ratio between the two successive volumes was 1.1.Successful ONB was considered to be positive response.The EV50 and 95 ％ confidence interval (CI) of 1.5 ％ lidocaine for ONB were calculated.Results The EV50 of 1.5 ％ lidocaine for ONB was 5.53 rnl and the 95 ％ CI was 5.10-6.00 ml.Conclusion The EV50 of 1.5 ％ lidocaine is 5.53 ml when used for ONB in patients undergoing TURBT.