Expression of PHF8 in human hepatocellular carcinoma and its clinical significance
10.3760/cma.j.issn.1007-8118.2013.12.007
- VernacularTitle:组蛋白去甲基化酶PHD锌指蛋白8在肝细胞癌中的表达及其临床意义
- Author:
Meng WEI
;
Lijie ZHENG
;
Huiwen SHI
;
Guangzhen LI
;
Zongli ZHANG
- Publication Type:Journal Article
- Keywords:
Hepatocellular carcinoma;
Histone demethylase,PHF8;
Prognosis
- From:
Chinese Journal of Hepatobiliary Surgery
2013;19(12):904-907
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of PHF8(PHD-finger protein 8) in human hepatocellular carcinoma (HCC) and its clinicopathologic significance.Methods The expression of PHF8 in 60 hepatocellular carcinoma samples as well as their natched paraneoplastic tissues,and 15 normal liver tissues were evaluated by immunohistochemistry.Statistical methods were used to analyse the relationship between the expression of PHF8 and the clinicopathological features of these patients.Results The PHF8-positive expression rate in the HCC samples was 55.0％ and it was significantly higher than that in the paraneoplastic tissues and the normal liver tissucs (16.7％,6.7％,respectively,P＜0.05).The expression of PHF8 was closely related to tumor size,tumor nodular numbers,pathological differentiation and TNM-staging (P＜0.05 for all).The 5-year disease-free survival and overall survival in the PHF8-positive group was significantly lower than that in the negative group (P＜0.05).Conclusions PHF8 was overexpressed in HCC samples,and its expression was closely associated with HCC clinicopathological features and prognosis of the patients.
