Efficacy and safety evaluation of low molecular weight heparin calcium combined with urease on intravenous thrombolytic therapy for acute myocardial infarction
10.3760/cma.j.issn.1008-6315.2013.12.009
- VernacularTitle:低分子肝素钙联合尿激酶静脉溶栓治疗心肌梗死的临床效果和安全性评价
- Author:
Dan HE
- Publication Type:Journal Article
- Keywords:
Low molecular weight heparin;
Urease;
Thrombolysis;
Myocardial infarction;
Clinical effect
- From:
Clinical Medicine of China
2013;29(12):1258-1260
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effect of low molecular weight heparin calcium combined with urease on intravenous thrombolytic therapy for myocardial infarction,and evaluate its safety.Methods One hundred and seven patients diagnosed myocardial infarction were randomly divided into the observation group (n =54) and control group (n =53),who were hospitalized in Yantai Central Hospital from January 2011 to December 2012.Patients in control group were given regular treatment plus basic support treatment for the symptomatic.Patients in the observation group were treated intravenous thrombolysis,subcutaneous low molecular weight heparin besides the basic treatment,10 d as a course of treatment.Observed the therapeutic effect in patients,observed and evaluated the safety of using two drugs in combination therapy group.Results (1) The recanalization rate of coronary artery in observation group was 83.33％ (45/54),higher than that in the control group (60.38％ (32/53),x2 =4.296 ; P ＜ 0.05).(2) The time of ST-T dropped back to 50％ in the observation group was (2.0 ±0.6) h,and recanalization time was (1.3 ±0.4) h,less than that in the control group (3.4 ± 0.5) h,(2.1 ± 0.3) h respectively),and the difference were significant (t =2.948,P ＜0.05 ; t =3.186,P ＜ 0.05).(3) Incidence of complications in the observation group was 44.44％ (24/54),significantly less than that of the control group (77.36％ (41/53) ; x2 =3.918,P ＜ 0.05).Two cases of the observation group were with reinfarction,accounting for 3.70％ and 9 cases in the control accounting for 16.98％.The difference was statistically significance (x2 =4.142 ; P ＜ 0.05).Conclusion The therapy plan of low molecular heparin combined with urease intravenous thrombolytic therapy for myocardial infarction can significantly improve the clinical effect of patients,reduce the complications and the incidence of myocardial infarction.It was proved as a safe and effective therapy plan in improving the prognosis of patients.
