The relationship of violent behavior with polymorphism of norepinephrine transporter gene, childhood abuse and their interaction effect in male adolescents
10.3760/cma.j.issn.1674-6554.2013.11.023
- VernacularTitle:去甲肾上腺素转运体基因和童年受虐交互作用与青少年暴力行为的关联研究
- Author:
Zhili ZOU
;
Huaqing MENG
;
Hua HU
;
Bo ZHOU
;
Zhongrui MA
;
Hongyin ZHANG
- Publication Type:Journal Article
- Keywords:
Adolescents;
Violent behavior Norepinephrine transporter
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2013;22(11):1031-1033
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the rs3785143 polymorphism of norepinephrine transporter gene,and investigate the influence of interaction effect between NET gene polymorphism and childhood abuse in adolescents with violent behavior.Methods Adolescent male offenders were divided into violent group (124 samples) and nonviolent group (120 samples).The rs3785143 polymorphisms of NET gene were measured by used SNaPshot SNP technology in 244 samples.Chi-square test was used to compare the distribution difference between three groups of each gene type and the allele frequency distribution.Results ①There was no statistically significant difference among violent group and nonviolent group in the genotype and allele frequencies of rs3785143 polymorphism (x2=0.753,0.022; all P＞0.05).②64.5％ violent adolescents have experience of childhood abuse,and 35.5％ had no history of abuse ;48.3％ nonviolent adolescents have experience of childhood abuse,and 51.7％ had no history of abuse(x2=6.50,P＜0.05).③There was not significant interaction between NET gene polymorphism and childhood abuse((OR=0.386,P＞0.05) 95％ CI (0.457-4.739)).Conclusions The NET gene polymorphism is not associated with violent behavior in male adolescents,and there was not interaction between NET gene polymorphism and childhood abuse.
