Study on the correlation of severity of acute pancreatitis with abnormal glucose metabolism and its prognosis
10.3760/cma.j.issn.1008-1372.2013.11.016
- VernacularTitle:急性胰腺炎严重程度与糖代谢异常的相关性及其预后
- Author:
Xin LUO
- Publication Type:Journal Article
- Keywords:
Acute disease;
Pancreatitis;
Glucose/metabolism;
Insulin resistance;
Prognosis
- From:
Journal of Chinese Physician
2013;15(11):1499-1501
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate correlation between severity of acute pancreatitis and abnormal glucose metabolism and its prognosis.Methods A total of 158 cases of patient admitted with acute pancreatitis in the Department of Digestion of our hospital from December 2004 and December 2012 were selected,and were divided into two groups:mild acute pancreatitis (MAP; n =68) and severe acute pancreatitis (SAP; n =90) according to disease severity.The patient's sugar metabolism such as fasting plasma glucose (FPG),postprandial plasma glucose (PPG) and acute physiology and chronic health evaluation Ⅱ (APACHEII) scores of two groups were detected.Correlation analysis was carried out between glucose metabolism index and APACHEII score.The prognosis of two groups was observed.Results The FPG,PPG,fasting insulin levels (FINS),and insulin resistance index (IRI) levels of SAP group were significantly higher than that of MAP group.The insulin sensitivity index (ISI) level was lower than that of MAP (P ＜0.01).APACHE Ⅱ score of acute pancreatitis (AP) patient was positively correlated with FPG,PPG,FINS,and IRI (P ＜0.05,P ＜ 0.01),and was negatively correlated with ISI (P ＜0.05).The incidence of pseudocyst (infection,abscess,and necrosis),acute lung injury or acute respiratory distress syndrome (ARDS),and death in SAP group were significantly higher than that in MAP group (P ＜ 0.05,P＜ 0.01).Conclusions There was a close relationship between AP severity and abnormal glucose metabolism.Therefore,in treating AP,ones should be actively controlled acute pancreatitis to prevent and reduce pancreatic necrosis,decrease blood glucose to normal range,and reduce morbidity and mortality.
