Examination of IL-1β, IL-6, and TNF α levels in serum and cerebrospinal fluid of patients with spontaneous subarachnoid hemorrhage and their relationship with systemic inflamatory response syndrome and multiple organ dysfunction syndrome
10.3760/cma.j.issn.1008-1372.2013.11.008
- VernacularTitle:自发性蛛网膜下腔出血后血清和脑脊液IL-1β、IL-6、TNF-α水平与SIRS及MODS的关系
- Author:
Baoguo LIU
;
Weibiao FU
;
Liming HE
;
Zelin WANG
;
Binliang GU
;
Jie LUO
- Publication Type:Journal Article
- Keywords:
Subarachnoid hemorrhage;
Interleukin-1 beta/blood;
Interleukin-1 beta/cerebrospinal fluid;
Interleukin-6/blood;
Interleukin-6/cerebrospinal fluid;
Tumor necrosis factor-alpha/blood;
Tumor necrosis factor-alpha/cerebrospinal fluid;
Systemic inflammatory re
- From:
Journal of Chinese Physician
2013;15(11):1466-1469
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the levels of IL-1β,IL-6 and tumor necrosis factor α (TNF α) in serum and cerebrospinal fluid of patients with spontaneous subarachnoid hemorrhage and their relationship with systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS).Methods The levels of interleukin-1β(IL-1β),interleukin-6(IL-6),and TNF α in serum and cerebrospinal fluid of patients with spontaneous subarachnoid hemorrhage were measured with enzyme-linked immunosorbent assay (ELISA).Results The levels of IL-1β,IL-6,and TNFα in serum and cerebrospinal fluid of patients with spontaneous subarachnoid hemorrhage were significantly higher than those of control group (P ＜ 0.05),but the increased time of these cytokines was different.Three cytokines in serum and the cerebrospinal fluid levels of IL-1β and IL-6 but not TNFα were significantly related to SIRS and MODS.Condusions The increased cytokine levels in serum and cerebrospinal fluid of patients with spontaneous subarachnoid hemorrhage may be related to SIRS and MODS,and the measurement of IL-1β,IL-6,and TNFαin serum,and IL-1β and IL-6 in cerebrospinal fluid of patients with spontaneous subarachnoid hemorrhage can be useful to predict and treat SIRS and MODS.
