Clinical observation on changes of cognitive function in patients with cerebral microbleeds
10.3760/cma.j.issn.1674-6554.2013.11.013
- VernacularTitle:脑微出血患者认知功能变化的临床观察
- Author:
Huiping ZHANG
;
Zufu ZHU
;
Shanshan HONG
;
Qiangbin LU
;
Jiangsheng YANG
;
Guoqing ZHOU
;
Qitao JIANG
- Publication Type:Journal Article
- Keywords:
Cerebral microbleeds;
Cognitive impairment;
Montreal cognitive assessment scale;
Clock drawing test
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2013;22(11):1001-1003
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the cerebral microbleeds (CMBs) and changes of cognitive function,and the possible mechanism of cognitive impairment caused by CMBs.Methods Sixty-eight micro-hemorrhage patients on susceptibility weighted imagine (SWI) sequences composed positive group,and sixty-eight patients selected without micro-hemorrhage in the SWI sequence and meeting the selection criteria as control group.At the same time,both two groups were assessed by MoCA and CDT scale inspection.Results CDT scores of CMBs group (2.00±0.88) were significantly lower than those of control group (3.76±0.53),and there was significantly different in the two groups (t=-3.27,P=0.00).At the same time,MoCA total scores and executive functions,naming,calculation,language,abstraction,recall scores of CMBs group were significantly lower than those of control group,and all of the groups were significantly different (t=-5.48,P=0.00; t=-4.36,P=0.00; t=-2.35,P=0.01 ; t=-2.49,P=0.02; t=-4.09,P=0.00; t=-4.63,P=0.00).CDT scores,MoCA total scores,executive functions,language,abstraction,memory scores between CMBs groups and control group were significantly different at all levels (P＜0.05).Executive functions,languages and calculated inter-group of mild CMBs,moderate CMBs,severe CMBs were significantly different (P＜0.05).The number of CMBs was negative correlation with total scores,executive function,language,and abstract (r=-0.675,P=0.000; r=-0.689,P=0.000; r=-0.536,P=0.000; r=-0.636,P=0.000).Conclusion The existence of CMBs and the number of CMBs are closely related to cognitive dysfunction.The more of CMBs,the more of obvious cognitive impairment.
