Clinical significance of visfatin and cTnI in patients with unstable angina pcetoris after coronary stent implantation
10.3760/cma.j.issn.1008-1372.2013.11.017
- VernacularTitle:不稳定性心绞痛经皮冠状动脉介入术后内脂素与肌钙蛋白Ⅰ变化及意义
- Author:
Hui HU
;
Kongjie LU
;
Gaohui YUAN
- Publication Type:Journal Article
- Keywords:
Angina,unstable;
Angioplasty,transluminal,percutaneous coronary;
Nicotinamide phosphoribosyltransferase/blood;
Troponin Ⅰ/blood
- From:
Journal of Chinese Physician
2013;15(11):1502-1504
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes and clinical significance of serum visfatin and cardiac troponin I (cTnI) level in patients with unstable angina pectoris (UAP) after percutaneous coronary intervention (PCI).Methods The 108 patients (aged 51 ～80 years) with UAP and 52 healthy subjects (aged 48 ～ 75) were enrolled.Before and after PCI at the different time,the serum levels of visfatin and cTnI were analyzed.During three years followed-up,the major adverse cardiac events (MACE) were assessed.MACE defined as cardiac death,myocardial infarction,target lesion revascularization anginal status.Results Twenty four hours later after PCI,compared with the level before PCI,the serum visfatin and cTnI levels of the UAP group were significantly increased (P =0.01) ; the serum Visfatin levels of the UAP group before PCI and 30 days later after PCI had no significant difference(P =0.12) ; Thirty days later after PCI,the serum cTnI levels of the UAP group were lower than them before PCI (P =0.02) ; high level visfatin and cTnI were independent predictors of MACE in UAP after PCI (OR =3.27,2.85) (P ＜0.05).The serum cTnI and visfatin levels were significantly positive correlation (r =0.523,P =0.01).Conclusions The serum visfatin and cTnI levels in patients with UAP after PCI increased transitorily,and they had certain value in predicting MACE.
