The expressions and clinical significance of STAT3, Bcl-2, and MMP2 in colorectal adenomas and adenocarcinomas
10.3760/cma.j.issn.1008-1372.2013.11.011
- VernacularTitle:STAT3,Bcl-2和MMP2在结直肠腺瘤和腺癌中的表达及其临床意义
- Author:
Aijiao WU
;
Xiaowei ZHANG
- Publication Type:Journal Article
- Keywords:
DNA-binding proteins/metabolism;
Trans-activators/metabolism;
Matrix metalloproteinase 2/metabolism;
Proto-oncogene proteins c-bcl-2/biosynthesis;
Colorectal neoplasms/metabolism;
Colorectal neoplasms/pathology;
Adenoma/metabolism;
Adenoma/pathology
- From:
Journal of Chinese Physician
2013;15(11):1478-1481
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of signal transducer and activator of transcription factor 3 (STAT3),Bcl-2,and matrix metalloproteinase 2 (MMP2) in colorectal adenomas and adenocarcinomas,and the relationship of those factors with the colorectal clinicopathological features and prognosis of intestinal adenocarcinomas,and explore their roles in invasion,metastasis,and prognosis of a colorectal cancer.Methods The samples were selected from Dongyang City People's Hospital from January 2011 to January 2012,including 50 cases of paraffin-coded colorectal mucosas with chronic inflammation,50 cases of paraffincoded colorectal adenomas,and 100 cases of paraffin-coded colorectal adenocarcinomas (35 cases with metastasis and 65 cases without distant metastasis).Envison two method was used to detect the expressions of STAT3,Bcl-2,and MMP2 in each sample.Results The expressions of STAT3,Bcl-2,and MMP2 in colorectal adenomas and adenocarcinomas were significantly higher than those in colorectal mucosas with chronic inflammation (P ＜ 0.05).The expressions of STAT3 and MMP2 in colorectal adenocarcinomas with distant metastasis were significantly higher than that those without distant metastasis (P ＜ 0.05).The expression of BCL-2 had no significant difference between colorectal adenocarcinomas with and without distant metastasis (P ＞ 0.05).Conclusions STAT3,Bcl-2 and MMP2 were associated with occurrence and development of colorectal carcinoma.STAT3 was associated with distant metastasis of colorectal carcinoma and might indicate a poor prognosis.STAT3 might be used as a candidate clinical sign for recurrence,metastasis,and poor survival prognosis of colorectal adenocarcinoma.
