Microglial Toll-like receptor 2 and cerebral ischemia
10.3760/cma.j.issn.1673-4165.2013.10.008
- VernacularTitle:小胶质细胞Toll样受体2与脑缺血
- Author:
Lingli CHEN
;
Mingshan REN
- Publication Type:Journal Article
- Keywords:
Toll-Like Receptor 2;
Brain Ischemia;
Microglia
- From:
International Journal of Cerebrovascular Diseases
2013;21(10):792-795
- CountryChina
- Language:Chinese
-
Abstract:
Microglia can be activated immediately after acute cerebral ischemia and play a role of double-edged sword of nerve repair and neurotoxicity.Studies in recent years have suggested that this dual role of microglia can be achieved by a Toll-like receptor 2 (TLR2) signal transduction pathway.Therefore,reasonable regulation of TLR2 expression of microglia may improve the therapeutic effect of cerebral ischemia to a certain extent.This article reviews the mechanisms of TLR2 in cerebral ischemia and the possible interventions.
