Effects of D-ribose on High-energy Phosphate Metabolism of Skeletal Muscle Tissues of Tired Mice
10.11842/wst.2013.09.010
- VernacularTitle:D-核糖对疲劳小鼠骨骼肌组织内高能磷酸物质代谢的影响
- Author:
Yan DING
;
Dan WU
;
Zhanhong JIA
;
Dandan LI
;
Yun WEI
;
Jinxin RUAN
;
Shuofeng ZHANG
;
Yikun SUN
- Publication Type:Journal Article
- Keywords:
D-ribose;
ATP;
ADP;
AMP;
IMP
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2013;(9):1916-1920
- CountryChina
- Language:Chinese
-
Abstract:
This article was aimed to study effect of D-ribose on the high-energy phosphate metabolism of skeletal muscle tissues of tired mice. The model was made by burden swimming. And then, the mice were divided into four groups, which were the model group, D-ribose group, caffeine group, and D-ribose with caffeine group). Intragastric administrations of drugs were given to all mice in four groups, three times per day. And all mice continued to swim for three days. The time of swimming was recorded. Gastrocnemius of mice were removed after swimming or 3 days later to measure the concentration of ATP, ADP, AMP and IMP with the HPLC. The results showed that compared with the control group, the time of burden s wimming was significantly prolonged for mice in the D-ribose group and the D-ribose with caffeine group. After three-day recovery, the concentration of ATP, AMP and IMP of gastrocnemius in the D-ribose group and the D-ribose with caffeine group mice was significantly increased. There was no significant difference in the caffeine group mice. It was concluded that D-ribose is involved in the high-energy phosphate metabolism of skeletal muscle tissues of tired mice . D-ribose promotes the recovery of ATP concentration in the gastrocnemius of tired mice, and prolongs the time of burden swimming. Therefore, it has a certain anti-fatigue effect .
