Application of Dry Process Granulation Technique in FKⅣ Granules Preparation

VernacularTitle:干法制粒技术在FKⅣ颗粒剂制备中的应用
Author: Jun QIAN ; Xia LIN ; Lili LIU ; Xingxing WANG ; Yun WU ; Wei XIAO
Publication Type:Journal Article
Keywords: FKⅣ granules; dry process granulation technique; orthogonal experiment; optimum technique
From: World Science and Technology-Modernization of Traditional Chinese Medicine 2013;(9):1990-1997
CountryChina
Language:Chinese
Abstract: This article was aimed to study the optimum technological conditions of roller compaction of FKⅣ gran-ules. This experimentation compared content of two granule preparation techniques which were the dry process gran-ulation and the wet process granulation, and adopted L9(34) orthogonal experiment to study the technological parame-ters of FKⅣ granules. The dry process granulation was selected. And factors such as roller pressure, roller speedand moisture content of power, which influence the result of granule yield were also studied in the dry process gran-ulation. The results showed that the optimum technological conditions were roller pressure at 5.0 Mpa, roller speed at 400 rpm, and moisture content of power at 3.0%. It was concluded that the roller compaction process of FKⅣ gran-ules was feasible in production which was able to meet the requirement of production.