Recent advances in surface modification of magnetic iron oxide nanoparticles and their applications for CTCs separation
10.3969/j.issn.1000-8179.20131123
- VernacularTitle:磁性氧化铁纳米粒子的表面修饰及其在CTCs分离中应用的研究进展
- Author:
Xiaolin HUANG
;
Hengyi XU
- Publication Type:Journal Article
- Keywords:
magnetic iron oxide nanoparticles;
surface modification;
circulating tumor cells;
separation
- From:
Chinese Journal of Clinical Oncology
2014;(1):56-59
- CountryChina
- Language:Chinese
-
Abstract:
Magnetic iron oxide nanoparticles (MIONs) have been widely used in biomedical fields, including targeted drug deliv-ery, magnetic resonance imaging, separation and enrichment of cancer cells, and tumor-targeted therapy. However, MIONs are increas-ingly necessary to ensure reduced toxicity, more stable colloidal dispersion, better biocompatibility, and higher magnetic responsive-ness. Thus, apart from the continuous improvement of material synthesis, specific surface modification of MIONs is essential to choose appropriate materials. This paper reviews the available methods and materials and their function in MION surface modification as well as their applications for the separation of circulating tumor cells.
