Recent development in preparation and application of drug-loaded magnetic nanoparticle-modified microcapsules
10.3969/j.issn.1000-8179.20131766
- VernacularTitle:携带磁性纳米颗粒载药微囊的制备及肿瘤治疗的应用研究进展
- Author:
Kun FANG
;
Fang YANG
;
Ning GU
- Publication Type:Journal Article
- Keywords:
magnetic nanoparticles;
magnetic targeting;
magnetic microcapsules;
controlled release;
hyperthermia combined che-motherapy
- From:
Chinese Journal of Clinical Oncology
2014;(1):9-12
- CountryChina
- Language:Chinese
-
Abstract:
Coupled magnetic nanoparticles in the microcapsule structure, such as magnetic microcapsules, can be delivered in specific organism or tissues under magnetic field exposure. Thus, the microcapsules can achieve active targeting functions by manipulat-ing the magnetic field. Based on the magnetic microcapsules, the antitumor drugs can also be loaded to realize magnetic response, which gives microcapsules sustained and controlled release advantages. To date, the drug microcapsules carrying magnetic nanoparti-cles have become promising novel delivery carriers for the treatment of tumor diseases. This paper mainly reviews the method of prepa-ration of the magnetic nanoparticle-coupled microcapsules, including liposomes, polyelectrolyte microcapsules, and polymer micro-spheres. The basic research progress of these microcapsules as anticancer drug carriers for the tumor therapy was also reviewed.
