Monitoring anti-metastasis effect of vinorelbine-encapsulated micelles on breast cancer by bioluminescence imaging
10.3969/j.issn.1000-8179.20131858
- VernacularTitle:活体自发光成像监测长春瑞滨纳米胶束抗乳腺癌转移机制研究
- Author:
Fayun ZHANG
;
Lei QIN
;
Wei LIANG
- Publication Type:Journal Article
- Keywords:
vinorelbine-encapsulated micelle;
bioluminescence imaging;
breast cancer;
lymphatic metastasis
- From:
Chinese Journal of Clinical Oncology
2014;(1):13-17
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Breast cancer metastasis is a major cause of death. Lymphatic metastasis is one of the two main metastatic ways that is crucial to the metastasis process of breast cancer. To treat breast cancer metastasis, we prepared micelle-based drug carrier for lymphatic delivery. Methods:We used in vivo bioluminescence imaging for real-time dynamic monitoring of the inhibitory effect of polyethylene glycol phospholipid micelle encapsulating vinorelbine on breast cancer metastasis. Results: Compared with the free vinorelbine, vinorelbine-encapsulated micelles (NanoVin) showed a significantly enhanced anti-tumor activity both in primary and met-astatic tumors. Conclusion:Intravenous administration of NanoVin markedly prevented the metastasis of tumor cells through both he-matogenous and lymphatic systems. This study provides a new approach for treatment of metastatic tumors. Bioluminescence imaging is a powerful tool to dynamically monitor tumor metastasis and clinical therapeutic effect of anticancer drugs.
