Intervention Effects of Xintongfang on Platelet-leukocyte Interaction in Patients of Coronary Heart Disease with Carotid Artery Plaque

VernacularTitle:心痛方对冠心病合并颈动脉斑块患者血小板-白细胞相互反应的影响
Author: Jinru FAN ; Yihong JIANG ; Jianxiang WANG ; Tong CHEN ; Bing DAI ; Shizhao HOU ; Yumeng HU
Publication Type:Journal Article
Keywords: Xintongfang; coronary heart disease; carotid artery plaque; PS; PSGL-1; PLA; PMA
From: Chinese Journal of Information on Traditional Chinese Medicine 2014;(1):19-21
CountryChina
Language:Chinese
Abstract: Objective To observe the intervention effects of Xintongfang on the expression of P-selectin (PS), P-selectin glycoprotein ligand-1 (PSGL-1), platelet-leukocyte aggregates (PLA) and platelet-monocyte aggregates (PMA) in patients of coronary heart disease with carotid artery plaque. Methods Sixty patients were randomly divided into Xintongfang group and the control group, with 30 cases in each group. Xintongfang group was given Xintongfang, the control group was given aspirin and atorvastatin calcium for two months. The expression of PS, PSGL-1, PLA and PMA were tested by flow cytometry before and after treatment. Results The expression of PS, PSGL-1, PLA and PMA in two groups were reduced (P<0.01). Xintongfang group had more obvious effects on the expression of PLA and PMA than the control group (P<0.05). Conclusion Xintongfang can reduce the degree of inflammatory in patients of coronary heart disease with carotid artery plaque by inhibiting platelet-leukocyte interaction.