The Clinical effect of T-cell CD40 ligand,IL-6 and hs-CRP expression on rheumatoid arthritis patients
10.3969/j.issn.1671-8348.2013.36.016
- VernacularTitle:类风湿性关节炎患者血清CD40L及IL-6hs-CRP表达及临床意义
- Author:
Jun TAN
;
Jianguo CHEN
- Publication Type:Journal Article
- Keywords:
arthritis,rheumatoid;
antigens,CD;
interleukin-6;
C-reactive protein
- From:
Chongqing Medicine
2013;(36):4402-4404
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate clinical significance and the variation of serum interleukin -6(IL-6) ,high-sensitivity C-reac-tive protein(hs-CRP) and T-cell CD40 ligand(CD40 L) in patients with rheumatoid arthritis (RA)(included activity group and stable group) .Methods 90 cases of RA patients in the observation group ,90 cases of healthy volunteers were selected as control group . Enhanced immunoturbidimetric assay was used in measurement of serum hs-CRP .Levels of CD40 L ,IL-6 were detected by enzyme-linked immunosorbent assay .Results BPC ,RF ,ESR ,hs-CRP ,IL-6 and CD40 L in peripheral serum of observation group were sig-nificantly higher than control group ,the differences were statistically significant (P<0 .05) .BPC ,ESR ,hs-CRP ,IL-6 and CD40 L in peripheral blood of patients in RA activity group were significantly higher than patients with RA in stable group ,the differences were statistically significant(P<0 .05) .RF ,ESR ,hs-CRP ,IL-6 and CD40L in peripheral serum of RA patients whose platelet ele-vated were significantly higher than RA patients whose platelet stay normal level ,the differences were statistically significant (t=6 . 070 ,3 .858 ,3 .272 ,3 .217 ,2 .253 ,P<0 .05) .Conclusion Serum hs-CRP ,IL-6 and CD40 L relate to RA inflammation closely .Com-bined detection can observe the condition changes and treatment effect in patients with RA .
