Effect of Shoutaiwan on Expression of α-enolase in Decidua Tissue of Recurrent Abortion Mice
10.3969/j.issn.1005-5304.2014.01.020
- VernacularTitle:寿胎丸对复发性流产小鼠蜕膜组织α-烯醇化酶表达的影响
- Author:
Zhanwang TAN
;
Lei LEI
;
Huifang LI
;
Wei ZHU
;
Qiong MENG
;
Lei LUO
;
Lili LU
- Publication Type:Journal Article
- Keywords:
Shoutaiwan;
recurrent abortion;
decidua tissues;
α-enolase;
mice
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2014;(1):65-68
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of Shoutaiwan on the expression ofα-enolase in the decidua tissue of recurrent abortion mice. Methods The abortion-prone CBA/J × DBA/2 matings were established as the model of recurrent abortion and the nonabortion-prone CBA/J×BALB/C matings were used as the model of normal pregnancy. The model of recurrent abortion CBA/J × DBA/2 of pregnant mice were randomly divided into model group and Shoutaiwan high-, medium-, low-dose groups, pregnant mice of every group were orally administrated in different doses. On the 14th day of pregnancy, the mice were killed. The expression ofα-enolase was detected by using immunohistochemical method and Western Blot. Results α-enolase expression in the model group was significantly higher than the normal pregnancy group (P<0.01). Compared with the model group, Shoutaiwan low-, medium- and high-dose group significantly decreasedα-enolase expression of pregnant mice (P <0.01). Compared with high-dose group, Shoutaiwan medium-and low-dose group showed no significant difference (P>0.05). Conclusion Shoutaiwan could down-regulate the expression ofα-enolase in the decidua tissues of recurrent abortion mice, which may be one of its mechanisms of preventing miscarriage.
