Effects of Volatile Oil of Fructus Evodia, Mustard Oil and Total Anthraquinone in Rheum on Percutaneous Absorption of Paeoniflorin in Vitro
10.3969/j.issn.1005-5304.2014.01.024
- VernacularTitle:吴茱萸挥发油、芥子油及大黄总蒽醌对芍药苷体外经皮渗透的影响
- Author:
Zhipan YAN
;
Yun LI
;
Shuchang WEI
;
Yongqi LIU
- Publication Type:Journal Article
- Keywords:
paeoniflorin;
penetration enhancers;
volatile oil of Fructus Evodia;
mustar total anthraquinone of Rheum d oil
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2014;(1):79-82
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of volatile oil of Fructus Evodia, mustar d oil and total anthraquinone in Rheum on the transcutaneous permeability of paeoniflorin. Methods Using intelligent transdermal diffusion cell and excised mice skin in vitro as transdermal barrier, the kinetics parameters such as cumulative permeation quantity, permeation rate and permeation lagged time of the three kinds of penetration enhancers on paeoniflorin were determined by HPLC in 12 hours. Results The penetration rate of volatile oil of Fructus Evodia, mustard oil and total anthraquinone in Rheum were 8.188 6, 3.411 7, 1.230 3 μg/(cm2?h), respectively, the enhancement ratios were 22.6, 9.40, 3.40, respectively, and the permeation lagged times were 0.93, 0.51, 0.83 h, respectively. Conclusion Three penetration enhancers all can enhance previously percutaneous absorption of paeoniflorin, which provides reference for the selection of the penetration enhancers of transdermal delivery.
